Stress, the aging brain, and the mechanisms of neuron death

Stress, the aging brain, and the mechanisms of neuron death /

Looking beyond the now widely recognized relationships between stress and physical illness, this accessible and engagingly written book suggests that stress and stress-related hormones can also endanger the brain.

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Bibliographic Details
Main Author: Sapolsky, Robert M.
Format: Book
Language:English
Published: Cambridge, Mass. : MIT Press, ©1992.
Subjects:
Neuroendocrinology.
Brain > Aging.
Cell death.
Neurons.
Glucocorticoids > Physiological effect.
Stress (Psychology)
Stress (Physiology)
Glucocorticoids.
Biological models.
Aging > physiology
Cell Survival
Glucocorticoids
Models, Biological
Stress, Physiological
Neuroendocrinology
Neurons
Stress, Psychological
Aging > Physiology
Cell survival
Neuroendocrinologie.
Cerveau > Vieillissement.
Cellules > Mort.
Neurones.
Glucocorticoïdes > Effets physiologiques.
Stress.
Glucocorticoïdes.
Modèles biologiques.
44.90 neurology.
Modèle biologique.
Stress > physiopathologie.
Survie cellulaire.
Vieillissement > Physiologie.
Altern.
Gehirn.
Glucocorticosteroide.
Hirnschädigung.
Celdood.
Veroudering (biologie, psychologie)
Zenuwstelsel.
Neuroendocrinologia.
Stress e fadiga.
Velhice (sociologia)
Hirnschädigung.
Table of Contents:
  • pt. I. The Glucocorticoid Cascade Hypothesis. 1. The Stress-Response and the Emergence of Stress-Related Disease. 2. An Introduction to the Adrenocortical Axis. 3. Glucocorticoid Concentrations in the Aged Rat: A Problem of Hypersecretion. 4. The Problem of Receptor Loss. 5. The Hippocampus as a Mediator of Glucocorticoid Feedback Regulation. 6. Glucocorticoid Neurotoxicity
  • pt. II. How Does a Neuron Die? 7. Glucocorticoids Endanger Hippocampal Neurons. 8. A Brief Interlude: Programmed Cell Death. 9. Metabolic Chaos I: The Mediators of Necrotic Neuronal Injury. 10. Metabolic Chaos Il: The Role of Energy Failure in Necrotic Neuronal Injury. 11. How Do Glucocorticoids Endanger the Hippocampal Neuron?
  • pt. III. How Depressing Is All of This? 12. Individual Differences and Adrenocortical Function: Why Do Some Individuals Secrete More Glucocorticoids Than Others? 13. Interventions at the Time of Neurological Insults. 14. Is This Relevant to the Human?

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