Stress, the aging brain, and the mechanisms of neuron death /
Looking beyond the now widely recognized relationships between stress and physical illness, this accessible and engagingly written book suggests that stress and stress-related hormones can also endanger the brain.
Saved in:
| Main Author: | |
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| Format: | Book |
| Language: | English |
| Published: |
Cambridge, Mass. :
MIT Press,
©1992.
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| Subjects: |
MARC
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| 100 | 1 | |a Sapolsky, Robert M. | |
| 245 | 1 | 0 | |a Stress, the aging brain, and the mechanisms of neuron death / |c Robert M. Sapolsky. |
| 260 | |a Cambridge, Mass. : |b MIT Press, |c ©1992. | ||
| 300 | |a xi, 427 pages : |b illustrations ; |c 26 cm | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a unmediated |b n |2 rdamedia | ||
| 338 | |a volume |b nc |2 rdacarrier | ||
| 500 | |a "A Bradford book." | ||
| 504 | |a Includes bibliographical references (pages 341-423) and index. | ||
| 505 | 0 | |a pt. I. The Glucocorticoid Cascade Hypothesis. 1. The Stress-Response and the Emergence of Stress-Related Disease. 2. An Introduction to the Adrenocortical Axis. 3. Glucocorticoid Concentrations in the Aged Rat: A Problem of Hypersecretion. 4. The Problem of Receptor Loss. 5. The Hippocampus as a Mediator of Glucocorticoid Feedback Regulation. 6. Glucocorticoid Neurotoxicity -- pt. II. How Does a Neuron Die? 7. Glucocorticoids Endanger Hippocampal Neurons. 8. A Brief Interlude: Programmed Cell Death. 9. Metabolic Chaos I: The Mediators of Necrotic Neuronal Injury. 10. Metabolic Chaos Il: The Role of Energy Failure in Necrotic Neuronal Injury. 11. How Do Glucocorticoids Endanger the Hippocampal Neuron? -- pt. III. How Depressing Is All of This? 12. Individual Differences and Adrenocortical Function: Why Do Some Individuals Secrete More Glucocorticoids Than Others? 13. Interventions at the Time of Neurological Insults. 14. Is This Relevant to the Human? | |
| 520 | |a Looking beyond the now widely recognized relationships between stress and physical illness, this accessible and engagingly written book suggests that stress and stress-related hormones can also endanger the brain. | ||
| 599 | |a MSF FY00 |9 LOCAL | ||
| 650 | 0 | |a Neuroendocrinology. | |
| 650 | 0 | |a Brain |x Aging. | |
| 650 | 0 | |a Cell death. | |
| 650 | 0 | |a Neurons. | |
| 650 | 0 | |a Glucocorticoids |x Physiological effect. | |
| 650 | 0 | |a Stress (Psychology) | |
| 650 | 0 | |a Stress (Physiology) | |
| 650 | 0 | |a Glucocorticoids. | |
| 650 | 0 | |a Biological models. | |
| 650 | 2 | |a Aging |x physiology |0 (DNLM)D000375Q000502 | |
| 650 | 2 | |a Cell Survival |0 (DNLM)D002470 | |
| 650 | 2 | |a Glucocorticoids |0 (DNLM)D005938 | |
| 650 | 2 | |a Models, Biological |0 (DNLM)D008954 | |
| 650 | 2 | |a Stress, Physiological |0 (DNLM)D013312 | |
| 650 | 2 | |a Neuroendocrinology |0 (DNLM)D009452 | |
| 650 | 2 | |a Neurons |0 (DNLM)D009474 | |
| 650 | 2 | |a Stress, Psychological |0 (DNLM)D013315 | |
| 650 | 4 | |a Aging |x Physiology | |
| 650 | 4 | |a Cell survival | |
| 650 | 6 | |a Neuroendocrinologie. |0 (CaQQLa)201-0089756 | |
| 650 | 6 | |a Cerveau |x Vieillissement. |0 (CaQQLa)201-0032952 | |
| 650 | 6 | |a Cellules |x Mort. |0 (CaQQLa)201-0110794 | |
| 650 | 6 | |a Neurones. |0 (CaQQLa)201-0065589 | |
| 650 | 6 | |a Glucocorticoïdes |0 (CaQQLa)201-0023812 |x Effets physiologiques. |0 (CaQQLa)201-0374337 | |
| 650 | 6 | |a Stress. |0 (CaQQLa)201-0000111 | |
| 650 | 6 | |a Glucocorticoïdes. |0 (CaQQLa)201-0023812 | |
| 650 | 6 | |a Modèles biologiques. |0 (CaQQLa)201-0051425 | |
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| 650 | 7 | |a Glucocorticoids |x Physiological effect. |2 fast |0 (OCoLC)fst00943681 | |
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| 650 | 7 | |a Stress (Psychology) |2 fast |0 (OCoLC)fst01134918 | |
| 650 | 7 | |a Glucocorticoïdes. |2 fmesh | |
| 650 | 7 | |a Modèle biologique. |2 fmesh | |
| 650 | 7 | |a Stress |x physiopathologie. |2 fmesh | |
| 650 | 7 | |a Survie cellulaire. |2 fmesh | |
| 650 | 7 | |a Vieillissement |x Physiologie. |2 fmesh | |
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